Question

The ester form of metronidazole, metronidazole benzoate, does not have the same bitterness issue sue to its very low water solubility. Metronidazole benzoate is available in powder form. How many grams of metronidazole benzoate would be needed to prepare 8 fluid ounces of the formulation (above) such that the patient would receive an equivalent dose of the API? Metronidazole MW=171.16; Metronidazole Benzoate MW=275.26 Weigh _____________g of metronidazole benzoate powder on electronic balance. (Round appropriately.)

Answer 1

Approximately 11.83 grams of metronidazole benzoate powder would be needed to prepare 8 fluid ounces of the formulation.

Step-by-step explanation:

The question asks how many grams of metronidazole benzoate powder would be needed to prepare 8 fluid ounces of a formulation such that the patient receives an equivalent dose of the active pharmaceutical ingredient (API). In order to calculate the gram amount, we need to know the concentration of the API in the formulation. Let's assume that the concentration of metronidazole benzoate in the formulation is 5% (w/v), which means there are 5 grams of metronidazole benzoate per 100 mL of formulation.

First, we need to convert the volume from fluid ounces to milliliters. One fluid ounce is approximately 29.57 mL, so 8 fluid ounces is equal to 236.59 mL.

Next, we can use the concentration and volume to calculate the amount of metronidazole benzoate needed. Since the concentration is given per 100 mL, we can set up a proportion:

5 grams/100 mL = x grams/236.59 mL

Cross-multiplying, we get:

100x = 5 * 236.59

x = (5 * 236.59) / 100 = 11.8295 grams

Rounding appropriately, we find that approximately 11.83 grams of metronidazole benzoate powder would be needed to prepare 8 fluid ounces of the formulation.