Question

A patient with peptic ulcer disease is found to require larger than usual doses of omeprazole to cure her peptic ulcer. Which drug metabolism phenotype is most likely present in this patient?

A.CYP2D6 poor metabolizer phenotype
B.CYP2D6 extensive metabolizer phenotype
C.CYP2C19 poor metabolizer phenotype
D.CYP2C19 extensive metabolizer phenotype
E.rapid acetylation phenotype

Answer 1

The most likely drug metabolism phenotype in a patient who requires larger doses of omeprazole to treat peptic ulcer disease is the CYP2C19 poor metabolizer phenotype.

Step-by-step explanation:

If a patient with peptic ulcer disease requires larger than usual doses of omeprazole to cure her peptic ulcer, it suggests that they may have a drug metabolism phenotype affecting the metabolism of omeprazole. Among the listed options, the most likely phenotype is CYP2C19 poor metabolizer phenotype (Option C). This is because omeprazole is metabolized primarily through the CYP2C19 enzyme pathway, and individuals with the poor metabolizer phenotype would have reduced metabolism leading to the need for larger doses to achieve therapeutic effect.