Final answer:
It is true that the acquisition of land was a primary motivator in early U.S. Indian policy, as evidenced by actions like the Indian Removal Act and the resulting displacements of Native American tribes.
Step-by-step explanation:
The assertion that acquisition of land was the most important motivating factor in the formulation of early U.S. Indian policy is true. During the early stages of the United States, the pressure of European settlers expanding westward and the government's desire for growth led to the formulation of policies that often resulted in the forceful relocation of Native American tribes to open up more land for agriculture, settlement, and resources exploitation. This period saw policies such as the Indian Removal Act of 1830, which aimed to move Native American tribes living east of the Mississippi River to lands west of the river, notably leading to the Trail of Tears.