Question

1. A rat weighing 500 g is to be induced for anesthesia using Ketamine (Ketaset) and Dexmedetomadine (dexdomitor) Calculate how much of each drug the rat would need and indicate what kind of syringe size you would choose to adiminster the compound. Show your work. The drug bottles with their concentrations are on the final page of this exercise. Ketamine Dosage: 75mg/kg Dexdomitor dosage: 250mcg/kg Dexdomitor is reversed with a drug called Antisedan. The volume of Antisedan always matches your volume of Dexdomitor. (this way if you need it in a pinch you don't have to do any mathl) What volume of Antisedan would we use for this rat

Answer 1

To induce anesthesia in a 500 g rat, 37.5 mg of Ketamine and 125 mcg of Dexmedetomidine are needed. A 1 ml syringe is appropriate for administration. The volume of Antisedan to reverse the effects of Dexmedetomidine will be equal to the volume of Dexmedetomidine administered.

Step-by-step explanation:

A student needs to calculate the correct dosage of Ketamine and Dexmedetomidine for a 500 g rat and also determine the volume of Antisedan required. To calculate the dosages of the two drugs, we will use the provided dosages of 75 mg/kg for Ketamine and 250 mcg/kg for Dexmedetomidine. Then, we'll calculate the volume required for each drug based on their concentrations. Since the volume of Antisedan should match that of Dexmedetomidine, their volumes will be equal.

Ketamine Calculation

The rat weighs 500 g or 0.5 kg. The dosage of Ketamine is 75 mg/kg. Therefore:

75 mg/kg x 0.5 kg = 37.5 mg of Ketamine is needed.

Dexmedetomidine Calculation

The dosage of Dexmedetomidine is 250 mcg/kg. Therefore:

250 mcg/kg x 0.5 kg = 125 mcg of Dexmedetomidine is needed.

Syringe Size Selection

The syringe size should be chosen to accurately measure the volume of the drugs. A small syringe such as a 1 ml syringe is suitable for these small volumes, allowing for precise dosage and minimal waste.

Antisedan Volume

The volume of Antisedan used should match that of Dexmedetomidine. Without the concentration of Dexmedetomidine, we cannot calculate the exact volume, but we can state that the volumes will be equal, and the same syringe can be used for administration.