Final answer:
PG's estimated creatinine clearance (CrCl), calculated using the Cockcroft-Gault equation with age, weight, and serum creatinine levels, is approximately 72.88 mL/min. This estimation does not account for body surface area corrections.
Step-by-step explanation:
To calculate the creatinine clearance (CrCl), a measure of kidney function, for PG who is a 74-year-old male, we will use the Cockcroft-Gault equation. The equation is as follows:
CrCl = ( (140 - age in years) × weight in kg ) / (72 × serum creatinine in mg/dL)
For males, this raw number is then adjusted by a correction factor for body surface area (BSA) when necessary.
Given that PG is 74 years old, weighs 210 lbs (95.25 kg), and has a serum creatinine of 1.3 mg/dL, his CrCl calculation (without BSA correction) would be:
CrCl = ((140 - 74) × 95.25) / (72 × 1.3)
This results in a CrCl of approximately 72.88 mL/min. However, for more accurate results, the calculated CrCl can be adjusted for BSA to equate it to an average body surface area of 1.73 m², although the additional information necessary for this calculation is not provided.
After calculating the CrCl, it can be compared to normal values for age. For an adult male over 40 years, normal values decrease by 6.5 mL/min for each decade of life. Comparing with the normal range helps determine the overall kidney function of PG. Keep in mind that these values and calculations are for estimation purposes and should be validated clinically. PG's estimated creatinine clearance is approximately 72.88 mL/min before considering BSA correction.