Final answer:
For the recipient cell to become an Hfr cell, the entire F factor would have to be incorporated into the recipient cell's chromosome.
Step-by-step explanation:
In the case of conjugation between an Hfr cell and an F- cell, for the recipient cell to become an Hfr cell, the entire F factor would have to be incorporated into the recipient cell's chromosome. This occurs when the F plasmid integrates into the bacterial chromosome through recombination between the plasmid and the chromosome. As a result, the recipient cell becomes an Hfr cell and can transfer chromosomal DNA to other cells through conjugation.