Final answer:
An Hfr donor has the F factor integrated into its main chromosome, while an F+ donor does not.
Step-by-step explanation:
An Hfr donor is an E. coli cell that has the F factor integrated into its main chromosome, allowing for transfer of chromosomal DNA to the recipient cell through conjugation. On the other hand, an F+ donor is an E. coli cell that contains the F factor in the form of a plasmid but does not have it integrated into the chromosome.