Final answer:
The second great wave occurred during the Black Death pandemic in the 14th century, which originated in Asia and spread to Europe, causing significant mortality.
Step-by-step explanation:
The second great wave occurred during the second major pandemic known as the Black Death. This pandemic happened during the 14th century and originated in Asia before spreading to Europe. It had a devastating impact, killing an estimated one-quarter of the population of Europe. The second wave of the pandemic, also known as the Great Plague, occurred in the 1660s.