Final answer:
In Paracetamol Effervescent formulations, ingredients serve specific functions such as reaction facilitation and product preservation, with ratios critical for effervescence. Sodium starch glycolate and sodium benzoate differ from starch and magnesium stearate in their role and chemical properties. Magnesium stearate is recommended as a lubricant for the manufacturing process of effervescent tablets.
Step-by-step explanation:
The function of each ingredient in the Paracetamol Effervescent Granule/Tablet formula is to contribute to the effectiveness, stability, and usability of the final product. The ratio of Citric: Tartaric: Bicarbonate is crucial for generating an efficient effervescent reaction, which releases carbon dioxide upon contact with water and helps to disintegrate the tablet quickly. The sodium starch glycolate differs from starch as it is specifically modified for use as a superdisintegrant, aiding in the rapid breakdown of the tablet in aqueous conditions. Meanwhile, sodium benzoate is a preservative, whereas magnesium stearate serves as a lubricant to facilitate tablet ejection from the die.
To prepare PCM effervescent granules, a suitable method includes blending the active and inactive components thoroughly, followed by a granulation process to form granules. These granules are then compacted into tablets. Magnesium stearate is a suitable lubricant for effervescent tablets as it not only ensures efficient tablet manufacturing but also is non-reactive with the effervescent agents.