Final answer:
The National Response Framework is in effect at all times and is applicable to all types and sizes of incidents, not just natural disasters or after Presidential declarations. It is a key part of national strategy for security and resilience against various threats.
Step-by-step explanation:
The question relates to the National Response Framework (NRF), which is a structured guide designed to ensure that all response partners across the nation understand domestic incident response. Contrary to options A and B, the National Response Framework is not focused solely on natural disasters nor is it activated only after a Presidential disaster declaration. Instead, it is in effect at all times and is applicable to all types of incidents, whether natural, technological, or human-caused, as stated in option C. It serves as a comprehensive framework that identifies the key principles, roles, and structures that organize how we respond to incidents. The NRF is part of a larger strategy to strengthen the security and resilience of the United States through systematic preparation for the threats that pose the greatest risk to the security of the nation, including acts of terrorism, cyber attacks, pandemics, and catastrophic natural disasters.