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Before a DNA molecule can replicate itself, it must make itself more compact. This is accomplished by the double helix coiling up on itself.

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Final answer:

The statement is true. Before DNA replication, the double helix must undergo compaction by coiling up on itself. This allows for efficient replication and segregation of DNA during cell division.

Step-by-step explanation:

True

Before a DNA molecule can replicate itself, it must make itself more compact. This is accomplished by the double helix coiling up on itself. The process of compaction involves the association of DNA with proteins called histones, which form nucleosomes. The nucleosomes then coil into a 30-nm chromatin fiber, and further compaction occurs to form chromosomes. This compact and coiled structure allows the DNA to be efficiently replicated and segregated during cell division.

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