Final answer:
The two main groups of participants in the case-control study are lung cancer patients (cases) and people without lung cancer (controls).
Step-by-step explanation:
In a case-control study investigating the association between exposure to wheat flour and the onset of lung cancer, the two main groups of participants are lung cancer patients (cases) and people without lung cancer (controls). The study compares the two groups to determine if there is an association between exposure to wheat flour and the development of lung cancer. The case group consists of individuals who have been diagnosed with lung cancer, while the control group consists of individuals who do not have lung cancer.