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The fact that all substances are toxic if given in large quantities is known as the __________

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Final answer:

The fact that all substances are toxic if given in large quantities is known as the dose makes the poison. This means that what may be dangerous in some amounts may not be dangerous in other amounts.

Step-by-step explanation:

The fact that all substances are toxic if given in large quantities is known as the dose makes the poison. This means that what may be dangerous in some amounts may not be dangerous in other amounts. For example, small amounts of selenium are required by living organisms for proper functioning, but large amounts may cause cancer. The effect of a certain chemical on an individual depends on the dose (amount) of the chemical.

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