Final answer:
When MAOI is combined with tyramine, it can cause a serious reaction known as the 'cheese effect', leading to a dangerous increase in blood pressure. Individuals taking MAOIs should avoid foods and beverages that are high in tyramine.
Step-by-step explanation:
When MAOI (Monoamine Oxidase Inhibitor) is combined with tyramine, it can cause a serious reaction known as the 'cheese effect'. This is because MAOIs block the enzyme monoamine oxidase, which normally breaks down tyramine in the body. When tyramine is not broken down, it can build up to high levels and cause a sudden release of large amounts of norepinephrine, a neurotransmitter.
The 'cheese effect' can lead to a dangerous increase in blood pressure, causing symptoms such as severe headache, sharp chest pain, palpitations, sweating, and even stroke or heart attack in extreme cases.
Therefore, it is important for individuals taking MAOIs to avoid foods and beverages that are high in tyramine, such as aged cheese, cured meats, pickled or fermented foods, and certain alcoholic beverages.