Final answer:
Secondary intention healing happens when an irregular large wound fills in with granulation tissue and heals without surgical closure, often resulting in a larger scar.
Step-by-step explanation:
An irregular large wound with blood clot, no closure, and where granulation tissue fills in the wound, leading to a large scar, is described by the term secondary intention. Secondary intention refers to the natural healing process of larger or gaping wounds that cannot be closed easily with sutures. This is in contrast to primary intention healing, which occurs when the edges of a wound are brought close together (often with stitches) and the wound heals with minimal scarring.
In secondary intention, due to the wound size or contamination, the edges cannot be approximated and the wound heals from the bottom up. This extensive healing process involves a significant amount of granulation tissue, which is eventually replaced by fibrous scar tissue resulting from collagen deposition by fibroblasts. This type of healing typically results in a larger and more noticeable scar compared to primary intention healing.