Final answer:
Phenoxybenzamine and phentolamine are two non-selective alpha blockers. The main difference between them is their duration of action and the specific conditions they are used to treat.
Step-by-step explanation:
Alpha blockers are a type of medication that blocks certain receptors in the adrenergic system. Two non-selective alpha blockers are phenoxybenzamine and phentolamine. These medications work by blocking both α₁ and α₂ adrenergic receptors, which are involved in the fight-or-flight response.
Phenoxybenzamine is typically used to treat conditions like pheochromocytoma and certain types of high blood pressure. It binds irreversibly to the alpha receptors, meaning its effects are long-lasting.
On the other hand, phentolamine is used in emergency situations, such as hypertensive crisis, as it has a shorter duration of action. It binds reversibly to the alpha receptors.
In summary, the difference between the two non-selective alpha blockers, phenoxybenzamine and phentolamine, lies in their duration of action and the specific conditions they are used to treat.