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Two non-selective alpha blockers. Difference between the two?

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Final answer:

Phenoxybenzamine and phentolamine are two non-selective alpha blockers. The main difference between them is their duration of action and the specific conditions they are used to treat.

Step-by-step explanation:

Alpha blockers are a type of medication that blocks certain receptors in the adrenergic system. Two non-selective alpha blockers are phenoxybenzamine and phentolamine. These medications work by blocking both α₁ and α₂ adrenergic receptors, which are involved in the fight-or-flight response.

Phenoxybenzamine is typically used to treat conditions like pheochromocytoma and certain types of high blood pressure. It binds irreversibly to the alpha receptors, meaning its effects are long-lasting.

On the other hand, phentolamine is used in emergency situations, such as hypertensive crisis, as it has a shorter duration of action. It binds reversibly to the alpha receptors.

In summary, the difference between the two non-selective alpha blockers, phenoxybenzamine and phentolamine, lies in their duration of action and the specific conditions they are used to treat.

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