Final answer:
Antibodies against desmoglein 1 and 3 are associated with pemphigus vulgaris, an autoimmune disease causing blistering of the skin and mucous membranes.
Step-by-step explanation:
Antibodies against desmoglein 1 and 3 are characteristic of an autoimmune disease called pemphigus vulgaris. This condition is characterized by blistering of the skin and mucous membranes and is caused by a malfunction in the immune system wherein antibodies attack desmoglein proteins that are critical for the adhesion between epidermal cells, leading to their separation and blister formation. Unlike disease-related conditions such as iatrogenic disease or immune complex diseases like rheumatoid arthritis and systemic lupus erythematosus, pemphigus vulgaris is specifically triggered by autoantibodies targeting the structural components of the skin.