Final answer:
Propranolol is the drug that goes through extensive first-pass hepatic metabolism.
Step-by-step explanation:
The drug that goes through extensive first-pass hepatic metabolism is Propranolol. First-pass metabolism refers to the process where a drug is metabolized by the liver before it reaches the systemic circulation. This can significantly alter the bioavailability and effectiveness of the drug.
For example, when Propranolol is taken orally, it undergoes extensive metabolism in the liver, resulting in a significant reduction in its bioavailability. As a result, lower doses are needed compared to drugs that do not undergo extensive first-pass metabolism.