Question

What serious adverse reaction can occur with the loop diuretic Furosemide?

A. Stevens-Johnsons syndrome
B. GI bleeding
C. Hypertension
D. Bradycardia

Answer 1

The serious adverse reaction that can occur with the loop diuretic Furosemide is Stevens-Johnson syndrome. This medication increases urination by inhibiting sodium and chloride reabsorption in the kidneys, which can lead to electrolyte imbalances.

Step-by-step explanation:

The serious adverse reaction that can occur with the loop diuretic Furosemide is Stevens-Johnson syndrome (A). Loop diuretics including Furosemide inhibit the reabsorption of sodium (Na+) and chloride (Cl-) ions in the ascending limb of the loop of Henle, which increases urination. This effect on urination is because by blocking the reabsorption of these ions, water is also not reabsorbed, leading to increased urine output, a process central to the drug's ability to manage conditions like hypertension and edema. However, this diuresis can also lead to potential electrolyte imbalances, which occasionally might result in severe reactions like Stevens-Johnson syndrome.