Final answer:
Amatoxins, found in poisonous mushrooms, have a mechanism of action (MOA) that involves the inhibition of RNA synthesis in animals.
Step-by-step explanation:
MOA of Amatoxins (poisonous mushrooms)
Amatoxins are toxic compounds found in poisonous mushrooms, such as the death-cap mushroom (Amanita phalloides). The main mechanism of action (MOA) of amatoxins is the inhibition of RNA synthesis in animals. Specifically, alpha-amanitin, a toxic component of Amanita phalloides, inhibits RNA synthesis. This disruption of RNA synthesis leads to the destruction of cells and organ failure, ultimately resulting in death.
Example:
When someone accidentally eats the death-cap mushroom, the amatoxins in the mushroom enter the body. The alpha-amanitin in the amatoxins specifically targets the RNA synthesis process in cells. By inhibiting RNA synthesis, the amatoxins cause severe damage to cells, leading to organ failure and death.