Final Answer:
The combination of "fever, fatigue, new-onset cardiac murmur" raises concerns about infective endocarditis, an inflammatory condition affecting the heart valves.
Step-by-step explanation:
These symptoms, when occurring together, are suggestive of infective endocarditis, an infection that involves the inner lining of the heart chambers and heart valves. Fever is a common symptom, indicating an inflammatory response, while fatigue can result from the overall strain on the cardiovascular system. The new-onset cardiac murmur is particularly significant as it suggests structural changes in the heart valves, which can occur due to infection.
Infective endocarditis requires prompt medical attention as it can lead to severe complications, including heart failure and embolism. Timely diagnosis and appropriate treatment, often involving antibiotics and sometimes surgical intervention, are crucial for managing this condition effectively.