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Pulmonary vascular smooth muscle proliferation (medial hypertrophy), intimal thickening & fibrosis, significant luminal narrowing of arteries (vasoconstriction)... if severe, plexiform lesions -- diagnosis? treatment?

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Final answer:

Pulmonary arterial hypertension (PAH) is the diagnosis that matches the symptoms described. Treatment options for PAH include medications to improve symptoms and slow down the progression of the disease, oxygen therapy, and lung transplantation in severe cases.

Step-by-step explanation:

Pulmonary arterial hypertension (PAH) is the diagnosis that matches the symptoms described. It is a condition characterized by pulmonary vascular smooth muscle proliferation (medial hypertrophy), intimal thickening & fibrosis, and significant luminal narrowing of arteries (vasoconstriction).

In severe cases, plexiform lesions may also be present. PAH is a rare, progressive disorder that affects the blood vessels in the lungs, leading to high blood pressure in the pulmonary arteries.

Treatment options for PAH include medications to improve symptoms and slow down the progression of the disease, oxygen therapy, and lung transplantation in severe cases.

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