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SIADH -> low plasma sodium, low plasma osmolality, inappropriately concentrated urine, and what type of volume status?

User VVP
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Final answer:

In SIADH, despite low plasma sodium and low plasma osmolality, patients have a euvolemic volume status due to an increase in total body water which causes dilutional hyponatremia, without significant net change in extracellular fluid volume.

Step-by-step explanation:

The condition SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion) is characterized by low plasma sodium, low plasma osmolality, inappropriately concentrated urine, and euvolemic volume status. Despite the low plasma sodium, the total body water increases, leading to dilutional hyponatremia. As a result, the individual's volume status is often normal or slightly increased, termed euvolemic, meaning there is no significant net increase or decrease in extracellular fluid volume. Regulation of urine volume and osmolarity are major functions of the collecting ducts, crucially influenced by ADH (antidiuretic hormone). An overproduction of ADH in SIADH leads to water retention and hyponatremia, but without associated peripheral edema typically seen with hypervolemia since the fluid is retained in proportion to the degree of hyponatremia.

User Sukhwinder
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