Final answer:
Dermatomyositis is an autoimmune disease with autoantibodies that attack muscle and skin tissue, with types including Anti-Jo-1 and Mi-2 being associated with the disease.
Step-by-step explanation:
The autoimmune disease, Dermatomyositis, is characterized by the presence of autoantibodies that primarily target and attack muscle and skin tissue, leading to inflammation and a distinctive skin rash. In addition to the clinical symptoms, specific autoantibodies can be found in the serum of patients with Dermatomyositis, serving as markers for the disease. Some of the distinct types of autoantibodies associated with Dermatomyositis include those against aminoacyl-tRNA synthetases (e.g., Anti-Jo-1), Mi-2, and others, reflecting a broader autoantibody profile that may be present in this condition. Like other autoimmune diseases such as Systemic Lupus Erythematosus and Myasthenia Gravis, the body's immune system mistakenly targets its own tissues in Dermatomyositis, resulting in diverse symptoms such as muscle weakness and skin changes.