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Hofman vs Zaitsev, which is thermodynamic and which is kinetic product?

User Petr Hejda
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Final answer:

In chemical reactions, the Zaitsev product is the thermodynamic product, being more stable and favored at high temperatures or over time, while the Hofmann product is the kinetic product, forming more quickly and less stable, favored at lower temperatures.

Step-by-step explanation:

The question regarding Hofmann vs Zaitsev involves understanding the difference between thermodynamic and kinetic products in chemical reactions. The Zaitsev product is typically the thermodynamic product which is favored under conditions that allow the reaction to reach equilibrium, usually at high temperatures or over a longer period. This product is more stable and is formed via the more substituted alkene when dealing with elimination reactions. On the other hand, the Hofmann product is considered the kinetic product and is favored under conditions that preserve the rate of formation, usually at lower temperatures or with bulky bases in elimination reactions. This product forms more quickly and is less stable compared to the Zaitsev product.