Final answer:
The intimal lining of a vessel can be damaged if the needle is manipulated after insertion, possibly leading to serious complications.
Step-by-step explanation:
Damage to the intimal lining of the vessel is likely to occur when the needle is manipulated after insertion. The intimal layer is the innermost lining of a blood vessel and is crucial in maintaining vascular integrity and blood flow. It is very delicate and can be easily damaged by physical interference such as needle movement, potentially leading to complications such as thrombosis or infection.