Final answer:
IgA vasculitis, or Henoch-Schönlein purpura, is characterized by high fever, body aches, nausea, vomiting, and a distinctive petechial rash, potentially leading to severe hypotension, ischemia, glomerulonephritis, or hepatitis due to a type III hypersensitivity reaction.
Step-by-step explanation:
The clinical manifestations of IgA vasculitis, also known as Henoch-Schönlein purpura (HSP), typically present with a combination of symptoms including high fever, headache, body aches, nausea and vomiting. Patients often develop a petechial rash as a direct consequence of the type III hypersensitivity inflammatory reaction, which is induced by the formation of immune complexes that deposit in tissues and blood vessels. This reaction can lead to more severe complications with potentially fatal hypotension and ischemia due to blood coagulation. Furthermore, a progression to glomerulonephritis or hepatitis is possible. The initial signs can mimic a cold, with a high fever followed by a macular or papular rash appearing three to five days later. Due to the accumulation of immune complexes, particularly IgG, inflammatory events cascade and may result in a range of symptoms including chills, fever, rash, vasculitis, and arthritis.
IgA vasculitis, also known as Henoch-Schönlein purpura (HSP), is characterized by a type III hypersensitivity inflammatory reaction induced by the formation of immune complexes and their deposition in tissues and blood vessels. The clinical manifestations of IgA vasculitis/HSP include:
High fever
Headache
Body aches
Nausea and vomiting
Petechial rash
Potentially fatal hypotension and ischemia due to blood coagulation
It is important to note that clinical manifestations may vary from person to person.