Final answer:
The dose of EPINEPHrine 1:1000 for a 4-year-old female who is not responding to treatments initiated under Protocol 4022 is based on her weight. The recommended dose of epinephrine for anaphylaxis in children is 0.01 mg/kg of body weight.
Step-by-step explanation:
The dose of EPINEPHrine 1:1000 for a 4-year-old female who is not responding to treatments initiated under Protocol 4022 would depend on her weight. The recommended dose of epinephrine for anaphylaxis in children is 0.01 mg/kg of body weight. Considering that the concentration of EPINEPHrine 1:1000 means 1 mg of epinephrine is in 1 mL of solution, we can calculate the dose using the formula:
Dose (mg) = Weight (kg) x 0.01 mg/kg
For example, if the child weighs 20 kg, the dose would be:
Dose (mg) = 20 kg x 0.01 mg/kg = 0.2 mg