Final answer:
Exclusion criteria for Fibrinolytic therapy include conditions that predispose patients to bleeding, like pregnancy, recent surgery, tuberculosis, pneumonia, and other specific health issues. Thrombolytic agents like tPA are contraindicated for hemorrhagic strokes and must only be used after a careful diagnostic process.
Step-by-step explanation:
The exclusion criteria for Fibrinolytic therapy, which is the administration of drugs known as thrombolytic agents to speed up the degradation of abnormal blood clots, include conditions that increase the risk of bleeding or where bleeding can have serious consequences. Conditions such as pregnancy, rheumatic fever, rheumatic arthritis, recent surgery such as an abruption placenta or abortion, active tuberculosis, acute pneumonia, recent pulmonary embolism, recent myocardial infarction, and acute pancreatitis can exclude a patient from receiving Fibrinolytic therapy. This is crucial because administering thrombolytic agents to patients with these conditions could lead to excessive bleeding or exacerbate existing problems.
Furthermore, for strokes that are hemorrhagic rather than thrombotic, giving thrombolytic therapy would be contraindicated as it could worsen the hemorrhage. Careful diagnosis is essential before starting Fibrinolytic therapy. Tissue plasminogen activator (tPA), a common thrombolytic agent, catalyzes the conversion of plasminogen to plasmin, helping to dissolve clots. To avoid complications, healthcare providers must assess each patient's risks based on their medical history and the presence of any exclusion criteria before initiating Fibrinolytic therapy.