Final answer:
Alternatives to ACE inhibitors include ARNIs, ARBs, and anti-platelet therapy, which can reduce mortality and CHF hospitalizations, lower blood pressure, and decrease cardiovascular events.
Step-by-step explanation:
For individuals with hypertension or heart failure who do not sufficiently respond to ACE inhibitors, alternatives such as Angiotensin-Receptor Neprilysin Inhibitors (ARNIs) may be prescribed. ARNIs, such as valsartan/sacubitril, combine the effects of neprilysin inhibition with angiotensin receptor blockade, offering a dual mechanism of action that has been shown to reduce mortality and hospitalizations related to congestive heart failure (CHF). Another alternative includes Angiotensin II Receptor Blockers (ARBs) like candesartan and losartan, which block the receptor for angiotensin II, a substance in the body that causes vessels to tighten, thus helping to relax blood vessels and lower blood pressure. Anti-platelet therapy such as dual anti-platelet therapy with clopidogrel and aspirin is utilized to reduce cardiovascular events. However, it is important to note that this therapy may not change the risk of death in individuals who are not experiencing an acute event.