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_______ ->Tissue factor (thromboplastin) -> prothrombin

Thrombin -> fibrinogen -> fibrin -> clot formation -> clot retraction

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Final answer:

The question relates to the coagulation cascade in blood clot formation, which involves the conversion of prothrombin to thrombin, and subsequently, thrombin converting fibrinogen into fibrin. Platelets play a crucial role in clot formation and retraction, while vitamin K is important for the activation of clotting factors.

Step-by-step explanation:

The process described in the question is part of the coagulation cascade, which is essential for blood clot formation when injury occurs. This process can be divided into three main phases:

  • Tissue factor (also known as thromboplastin) initiates the extrinsic pathway in response to tissue damage.
  • Prothrombin is then converted to thrombin by the enzyme prothrombinase, an action that takes place in the common pathway of blood coagulation.
  • Thrombin, in turn, converts fibrinogen (factor I) into fibrin, which then forms the basis of a blood clot. This clot is further reinforced by factor XIII, which stabilizes the fibrin network.

Platelets contribute to the formation of a clot by adhering to the site of injury and releasing substances that activate other platelets and clotting factors. Clot retraction occurs when contractile proteins within the platelets pull the edges of the clot together, expelling serum and tightening the clot, much like tightening shoelaces. A consistent supply of vitamin K is essential for the activation of several clotting factors, and deficiencies can lead to blood clotting disorders.

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