Final answer:
It is not safe to take Zyban with monoamine oxidase inhibitors due to the risk of severe and life-threatening side effects.
Step-by-step explanation:
No, it is not safe to take Zyban (bupropion) in conjunction with monoamine oxidase inhibitors (MAOIs). Doing so could result in severe, life-threatening side effects, such as a hypertensive crisis (a dangerous increase in blood pressure) or serotonin syndrome (a potentially fatal condition caused by excessive levels of serotonin in the brain). Zyban itself is an atypical antidepressant that works differently than both MAOIs and selective serotonin reuptake inhibitors (SSRIs), being a norepinephrine-dopamine reuptake inhibitor (NDRI). It's designed to aid in smoking cessation and also for the treatment of depression. However, using it in combination with MAOIs is contraindicated due to the risk of significant drug interactions.