Final answer:
P2Y12 inhibitors can cause dyspnea as a side effect, along with other potentially irreversible effects such as vertigo, loss of balance, and polyneuropathy.
Step-by-step explanation:
A student has inquired about a P2Y12 inhibitor that has dyspnea as a side effect. P2Y12 inhibitors are a class of medications used to prevent blood clots and are commonly prescribed for conditions such as acute coronary syndrome or after certain heart procedures. Dyspnea, or difficulty breathing, is a known side effect of some P2Y12 inhibitors. It is important to note that other side effects can occur with these medications, such as vertigo, loss of balance, and polyneuropathy, some of which have been labeled as potentially irreversible by the FDA. Efforts to improve the therapeutic index of related drugs, like mefloquine, by modifying the piperadine side-chain have been abandoned due to challenges including poor predictive models of CNS toxicity and the stigma attached to the quinoline methanol class. Additionally, trials with enantiomerically pure mefloquine, which is currently marketed as a racemic mixture, have not shown significant improvements in tolerability.