Final answer:
Loop diuretics, such as Furosemide (Lasix), inhibit the reabsorption of Na+ and Cl- ions in the ascending limb of the loop of Henle in the nephron. This leads to increased excretion of these ions in the urine, resulting in increased urination. Loop diuretics have increased bioavailability and longer half-lives compared to other diuretics.
Step-by-step explanation:
Loop diuretics, such as Furosemide (Lasix), are drugs that are commonly used to treat hypertension.
These drugs work by inhibiting the reabsorption of Na+ and Cl- ions in the ascending limb of the loop of Henle in the nephron.
By blocking the reabsorption of these ions, loop diuretics prevent them from being retained by the body, leading to increased excretion of Na+ and Cl- in the urine.
This increase in excretion ultimately leads to greater urine production and helps to decrease the volume of fluids in the body.
Loop diuretics have increased bioavailability and longer half-lives compared to other diuretics, which means they are more easily absorbed by the body and remain active in the system for a longer period of time.
What is meant by Loop diuretic with increased bioavailability and longer half-life?