Final answer:
Apixaban (Eliquis) should be used with caution or avoided in certain situations, including allergies, bleeding disorders or history, and renal impairment.
Step-by-step explanation:
Apixaban (Eliquis) is a medication used to prevent blood clots in certain medical conditions such as atrial fibrillation, deep vein thrombosis, and pulmonary embolism. However, there are situations where caution should be exercised or the use of apixaban should be avoided.
One situation is when a patient has a known allergy or hypersensitivity to apixaban or any of its components. This can cause an allergic reaction, which may be life-threatening.
Another situation is when a patient has an active bleeding disorder or a history of gastrointestinal bleeding, intracranial bleeding, or organ bleeding. Apixaban can increase the risk of bleeding, so caution should be taken in such cases to avoid further complications.
Lastly, caution should be exercised in patients with renal impairment. Apixaban is primarily eliminated through the kidneys, and reduced kidney function can lead to higher drug levels in the body, increasing the risk of bleeding. Dose adjustments may be necessary in these patients.