Final answer:
Drugs that increase insulin secretion and insulin itself carry the risk of hypoglycemia.
Step-by-step explanation:
Hypoglycemia is the major risk associated with drugs that increase insulin secretion, such as sulfonylureas. Insulin itself, in any formulation, also carries a risk of hypoglycemia. Hypoglycemia is characterized by symptoms such as feelings of hunger, sweating, shakiness, and weakness and can be a potentially dangerous condition if not promptly treated.