Final answer:
The lack of functional Na+-K+-ATPase in erythrocytes of people with glycolysis dysfunction leads to intracellular sodium accumulation, cellular swelling, and RBC lysis.
Step-by-step explanation:
The lack of functional Na+-K+-ATPase in erythrocytes of people with glycolysis dysfunction leads to the accumulation of intracellular sodium, cellular swelling, and lysis of the red blood cells (RBCs).
When the basolateral Na+/K+-ATPase cannot maintain its activity due to the deficiency in energy production from glycolysis, the intracellular sodium concentration increases. This increase in intracellular sodium causes water to passively diffuse into the RBCs, leading to their swelling.
The swelling and lysis of RBCs result in hemolytic anemia and an increase in plasma bilirubin levels, which can lead to jaundice. Additionally, the accumulation of reaction intermediates affects tissue oxygenation, causing a 'right shift' in the hemoglobin oxygen saturation curve and decreased oxygen affinity for hemoglobin.