Final answer:
During the post examination or post analytical phase, results are analyzed, including direct observation and chromatographic separation of analytes, which are essential for accurate pharmacokinetic studies in the drug discovery and development process.
Step-by-step explanation:
The post examination or postanalytical phase is a critical part of laboratory testing and includes all steps taken after the actual testing has been completed. This phase involves the direct observation of test outcomes, such as assessing the appearance of media, slides, or tubes. It is the point at which professionals analyze sample analysis results and determine whether the tests support hypotheses or formulations made before testing.
During the drug discovery and development (DDD) process, chromatographic techniques like Liquid Chromatography (LC) play an essential role. LC is used to separate analytes from endogenous substances and metabolites, ensuring accurate pharmacokinetic measurements and preventing issues like ion suppression or enhancement that can affect results. Table 2.1.6 illustrates examples of pharmacokinetic investigations that are performed during DDD, showcasing the rigorous analytical conditions and parameters that are validated post-analysis to confirm a drug's efficacy and safety profile.