Final answer:
Primary sclerosing cholangitis is the disease associated with middle-aged men with UC and a positive p-ANCA. It causes inflammation and scarring of the bile ducts.
Step-by-step explanation:
The disease associated with middle-aged men with UC (ulcerative colitis) and a positive p-ANCA (perinuclear antineutrophil cytoplasmic antibody) is primary sclerosing cholangitis. Primary sclerosing cholangitis is a chronic liver disease that causes inflammation and scarring of the bile ducts, leading to impaired bile flow. It is commonly found in patients with UC and is characterized by the presence of p-ANCA.
Primary sclerosing cholangitis can lead to various complications, such as liver cirrhosis, bile duct strictures, and an increased risk of developing cholangiocarcinoma (a type of liver cancer). Treatment options include medications to manage the symptoms, endoscopic procedures to relieve bile duct strictures, and liver transplantation in severe cases.
It is important for middle-aged men with UC and a positive p-ANCA to be regularly monitored for the development of primary sclerosing cholangitis, as early diagnosis and intervention can help manage the disease and prevent complications.