Final answer:
Buprenorphine and methadone are the two long-acting drugs used to help manage opioid withdrawal symptoms, often used as part of medication-assisted treatment (MAT).
Step-by-step explanation:
The two long-acting drugs commonly used to attenuate opioid withdrawal symptoms are buprenorphine and methadone. Buprenorphine is a partial opioid agonist, which can reduce cravings and withdrawal symptoms without producing the euphoria associated with opioids. Methadone is a full opioid agonist, which also diminishes withdrawal symptoms and the desire to use opioids.
Both medications can be essential components of medication-assisted treatment (MAT) for opioid dependence and are typically administered under a healthcare provider's supervision to ensure safety and efficacy. They help individuals on the path to recovery by managing withdrawal symptoms and reducing the risks associated with opioid use, such as overdose.