Final answer:
A large-bore needle should be inserted into the second intercostal space in the midclavicular line (2ICS MCL) in a tension pneumothorax.
Step-by-step explanation:
In a tension pneumothorax, a large-bore needle should be inserted into the second intercostal space in the midclavicular line (2ICS MCL) to relieve the build-up of air and collapsed lung. This is because the 2ICS MCL provides direct access to the pleural space where the pneumothorax occurs.