Final answer:
Neuromuscular blockers, like Botulinum toxin, inhibit acetylcholine release, causing paralysis, and should never be used without medical supervision and the ability to provide artificial respiration.
Step-by-step explanation:
Neuromuscular blockers should never be used without appropriate medical supervision and support, specifically without the means to provide artificial respiration. These agents, such as Botulinum toxin (BONT), can cause flaccid paralysis by inhibiting the release of the neurotransmitter acetylcholine from motor neurons at the neuromuscular junction. This prevents the muscles from contracting, leading to muscle relaxation and potentially total paralysis of the respiratory muscles, which would make it impossible for a person to breathe without assistance. For conditions like myasthenia gravis, where muscle weakness is due to the impaired function of ACh receptors, neuromuscular blockers can be life-threatening.