Question

You give amiodarone 300 mg (first dose) and finish the cycle of CPR. Upon a rhythm check, you see, the patient has converted to a normal sinus rhythm and has a pulse (ROSC). As you begin the post-arrest phase, the patient has a short run of VT. In light of the continued arrhythmia, you are instructed to start an amiodarone drip for post-resuscitation maintenance therapy. What is maximum cumulative dose for amiodarone in a 24 hour period?

Answer 1

The maximum cumulative dose of amiodarone in a 24-hour period is typically limited to 2.2 grams.

Step-by-step explanation:

The maximum cumulative dose of amiodarone in a 24-hour period is typically limited to 2.2 grams.

Amiodarone is an antiarrhythmic medication commonly used for the treatment of ventricular arrhythmias. When administered as a drip for post-resuscitation maintenance therapy, the usual starting dose is 1 mg/minute for the first 6 hours, followed by 0.5 mg/minute for the next 18 hours. This dosing regimen helps to prevent potential toxicity associated with higher cumulative doses.

It's important to note that the specific dosing recommendations for amiodarone may vary depending on the individual patient and the judgment of the medical team.