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Which produces more errors? Why? Trx or Replication?

User Defrex
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Final answer:

Replication has a higher fidelity than transcription, meaning it produces fewer errors because of proofreading mechanisms present during DNA replication. RNA polymerases lack these proofreading activities, which leads to a higher error rate in transcription.

Step-by-step explanation:

The student asked which produces more errors, transcription (Trx) or replication. In the context of molecular biology, both processes are crucial for cellular function. Transcription (Trx) is the process by which the information in a strand of DNA is copied into a new molecule of messenger RNA (mRNA). Replication, on the other hand, is the process by which a double-stranded DNA molecule is copied to produce two identical DNA molecules.

Replication has a higher fidelity than transcription. This means that replication tends to have fewer errors compared to transcription. The reason behind this is the existence of proofreading mechanisms during DNA replication. DNA polymerases, the enzymes responsible for DNA synthesis, have the ability to remove nucleotides that are incorrectly paired. On the contrary, RNA polymerases, the enzymes that synthesize RNA during transcription, lack such proofreading activity, resulting in a relatively higher error rate for transcription.

Furthermore, because DNA serves as the long-term storage of genetic information, it is imperative that replication errors are minimized to prevent mutations from being passed on to future generations. In contrast, mRNA molecules are temporary and are quickly degraded within the cell, so the consequences of errors in transcription are generally less severe.

User Gratzy
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