Final answer:
Gierke's Disease, also known as Glycogen Storage Disease Type Ia (GSD Ia), is a genetic disorder that affects the metabolism of glycogen in the body. It is caused by a deficiency in the enzyme glucose-6-phosphatase, which is responsible for breaking down glycogen into glucose.
Step-by-step explanation:
Gierke's Disease, also known as Glycogen Storage Disease Type Ia (GSD Ia), is a genetic disorder that affects the metabolism of glycogen in the body. It is caused by a deficiency in the enzyme glucose-6-phosphatase, which is responsible for breaking down glycogen into glucose. Without this enzyme, glycogen builds up in the liver and kidneys, leading to various symptoms.
The cellular and molecular basis of Gierke's Disease involves the impaired glucose metabolism and storage in the liver due to the deficiency of glucose-6-phosphatase. This leads to the accumulation of glycogen and a lack of glucose production, resulting in low blood sugar levels. The molecular basis of the disease is the mutation in the G6PC gene, which codes for the glucose-6-phosphatase enzyme.
To understand the cellular and molecular basis of Gierke's Disease further, it is important to study the biochemistry, genetics, and pathophysiology of glycogen metabolism and the role of glucose-6-phosphatase in glucose homeostasis.