Question

A patient with a diagnosis of TB will be taking INH as part of the anti-TB therapy. When reviewing the patient's chart, the nurse finds documentation that the patient is a "slow acetylator." This means that:

A.the dosage of INH may need to be lower to prevent INH accumulation.
B.the dosage of INH may need to be higher because of the slow acetylation process.
C.he should not take INH.
D.he will need to take a combination of anti-TB drugs for successful therapy.

Answer 1

A slow acetylator patient may need a lower dosage of INH in the anti-TB therapy to prevent INH accumulation.

Step-by-step explanation:

A patient who is a 'slow acetylator' will require a lower dosage of isoniazid (INH) as part of anti-TB therapy. Slow acetylation refers to a genetic variation in the way the drug is metabolized in the body. This means that the patient metabolizes INH at a slower rate, which can lead to higher levels of the drug in the system if the dosage is not adjusted. Lowering the dosage helps prevent INH accumulation and potential side effects.