Question

A patient is receiving cidofovir (Vistide) as part of treatment for a viral infection, and the nurse is preparing to administer probenecid, which is also ordered. Which is the rationale for administering probenecid along with the cidofovir treatment?

a. Probenecid has a synergistic effect when given with cidofovir, thus making the antiviral medication more effective.
b. The probenecid also prevents replication of the virus.
c. Concurrent drug therapy with probenecid reduces the nephrotoxicity of the cidofovir.
d. The probenecid reduces the adverse gastrointestinal effects of the cidofovir.

Answer 1

The rationale for administering probenecid along with cidofovir treatment is to reduce the nephrotoxicity of cidofovir.

Step-by-step explanation:

The rationale for administering probenecid along with cidofovir treatment is c. Concurrent drug therapy with probenecid reduces the nephrotoxicity of the cidofovir. Cidofovir is known to have potential nephrotoxicity, meaning it can cause damage to the kidneys. Probenecid is given to help reduce the risk of kidney damage by increasing the elimination of cidofovir from the body through the kidneys.