Final answer:
Erythema infectiosum, or Fifth disease, caused by parvovirus B19, frequently starts with cold-like symptoms and progresses to a distinctive red facial 'slapped cheek' rash, with a secondary rash later appearing on the body.
Step-by-step explanation:
Initial Signs and Symptoms of Erythema Infectiosum
Erythema infectiosum, also known as Fifth disease, is a common childhood illness caused by parvovirus B19. Initially, individuals may present cold-like symptoms such as a headache, fever, and upset stomach. These are followed several days later by a distinctive red facial rash, often described as a "slapped cheek" rash. As the illness progresses, a secondary rash may develop on the limbs and trunk before gradually fading to a lacy pattern over time.