Question

A client diagnosed with tuberculosis is taking isoniazid. To prevent a food and drug interaction, what should the nurse advise the client to avoid?

1. Chicken
2. Red wine
3. Sour cream
4. Apple juice

Answer 1

A client on isoniazid for tuberculosis should avoid red wine to prevent potential adverse interactions, as isoniazid acts as a monoamine oxidase inhibitor and can affect tyramine and histamine levels.

Step-by-step explanation:

The nurse should advise the client taking isoniazid for the treatment of tuberculosis to avoid consuming red wine. Isoniazid is an antimetabolite medication that is used in combination with other drugs like rifampin or streptomycin to treat tuberculosis. Its effectiveness can be compromised by certain food and drug interactions. One of the most significant interactions is with tyramine and histamine-containing foods, typically found in aged or fermented items, such as red wine. Consumption of these can lead to adverse effects because isoniazid is a monoamine oxidase inhibitor (MAOI), which means it can increase the levels of tyramine and histamines in the body, possibly leading to dangerous increases in blood pressure and other side effects.