Final answer:
Cocaine affects the synaptic activity by blocking the reuptake of dopamine and increasing adrenergic function involving norepinephrine, thus the correct answer is D. dopamine and norepinephrine.
Step-by-step explanation:
The cocaine effects involve changes in synaptic activity which relate to dopamine and norepinephrine. Cocaine acts as a stimulant by blocking the reuptake of dopamine into presynaptic neurons, increasing the amount of dopamine in the synaptic cleft. This leads to enhanced stimulation of the pleasure centers in the brain and is responsible for the drug's euphoric 'high' and its addictive properties. Furthermore, cocaine can increase adrenergic function, which relates to the neurotransmitter norepinephrine. Thus, the correct answer to which neurotransmitters are affected by cocaine is D. dopamine and norepinephrine.